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The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast.

Original publication

DOI

10.1534/genetics.113.150839

Type

Journal article

Journal

Genetics

Publication Date

07/2013

Volume

194

Pages

785 - 789

Keywords

Dsn1, Ipl1/Aurora B protein kinase, chromosome segregation, kinetochore, Aurora Kinase B, Chromosomal Proteins, Non-Histone, Chromosome Segregation, Gene Expression Regulation, Fungal, Kinetochores, Microtubules, Mitosis, Nuclear Proteins, Phosphorylation, Protein Interaction Maps, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins