Env-specific IgG and IgM were detected in 25 and 60%, respectively, of volunteers immunized with NYVAC expressing clade C gp120. The serum sample with the highest IgM titre but undetectable IgG neutralized the homologous isolate with a reciprocal IC90 titre of 7.8 in the absence of complement, and 24.4 in the presence of complement (P = 0.0003). These results suggest that vaccine-induced, Env-specific IgM may have antiviral activity and should be subjected to further investigation.

Original publication

DOI

10.1097/QAD.0b013e32803277f9

Type

Journal article

Journal

AIDS

Publication Date

19/02/2007

Volume

21

Pages

524 - 527

Keywords

AIDS Vaccines, HIV Antibodies, HIV Envelope Protein gp120, HIV-1, Humans, Immunoglobulin G, Immunoglobulin M, Viral Vaccines