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The full potential of organ transplantation has not yet been realized because of the hazards associated with the long-term use of immunosuppressive drugs. Modern research into mechanisms of immune tolerance offers the promise of reprogramming the immune system, so as to harness the body's natural tolerance mechanisms in the service of graft acceptance. This would allow the minimization of immunosuppressive treatment and offers the prospect of eventually weaning transplant recipients off their drugs.

Original publication

DOI

10.1126/science.1099538

Type

Journal article

Journal

Science

Publication Date

09/07/2004

Volume

305

Pages

209 - 212

Keywords

Animals, Biomarkers, Bone Marrow Transplantation, Graft Enhancement, Immunologic, Graft Rejection, Graft Survival, Humans, Immunosuppressive Agents, Lymphocyte Depletion, T-Lymphocytes, Transplantation Chimera, Transplantation Conditioning, Transplantation Immunology, Transplantation Tolerance