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Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.

Original publication

DOI

10.1016/0167-5699(93)90040-R

Type

Journal article

Journal

Immunol Today

Publication Date

06/1993

Volume

14

Pages

247 - 251

Keywords

Animals, Antibodies, Monoclonal, Autoimmune Diseases, Graft Rejection, Humans, Immune Tolerance, Immunosuppressive Agents, Major Histocompatibility Complex, T-Lymphocytes