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We have developed a rapid and simple procedure for the elimination of mature T-cells from the donor marrow using a single incubation with the monoclonal antibody Campath-1 and donor complement. This resulted in a reduction of T-cell contamination to a mean of 1%. This regimen reduced the incidence of acute graft-versus-host disease significantly in 21 consecutive bone marrow grafts in 18 patients with leukaemia and non-Hodgkin's lymphoma. Purging was responsible for an increased incidence of graft rejection in HLA-identical transplants (13%).

Type

Journal article

Journal

Br J Haematol

Publication Date

11/1986

Volume

64

Pages

479 - 486

Keywords

Adolescent, Adult, Antibodies, Monoclonal, Bone Marrow, Bone Marrow Cells, Bone Marrow Transplantation, Cell Separation, Complement System Proteins, Female, Graft vs Host Disease, Humans, Male, T-Lymphocytes