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Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.

Original publication

DOI

10.1080/09687680802552257

Type

Journal article

Journal

Mol Membr Biol

Publication Date

12/2008

Volume

25

Pages

677 - 682

Keywords

Crystallography, X-Ray, Deoxycholic Acid, Escherichia coli, Escherichia coli Proteins, Multidrug Resistance-Associated Proteins, Mutant Proteins