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Quantifying an imaging modality's ability to reproduce results is important for establishing its utility. In magnetic resonance spectroscopic imaging (MRSI), new acquisition protocols are regularly introduced which improve upon their precursors with respect to signal-to-noise ratio (SNR), total acquisition duration, and nominal voxel resolution. This study has quantified the within-subject and between-subject reproducibility of one such new protocol (reduced-field-of-view density-weighted concentric ring trajectory (rFOV-DW-CRT) MRSI) by calculating the coefficient of variance of data acquired from a test-retest experiment. The posterior cingulate cortex (PCC) and the right superior corona radiata (SCR) were selected as the regions of interest (ROIs) for grey matter (GM) and white matter (WM), respectively. CVs for between-subject and within-subject were consistently around or below 15% for Glx, tCho, and Myo-Ins, and below 5% for tNAA and tCr.

Original publication

DOI

10.3390/tomography10040038

Type

Journal article

Journal

Tomography

Publication Date

29/03/2024

Volume

10

Pages

493 - 503

Keywords

imaging, magnetic, non-Cartesian, nuclear, reproducibility, resonance, spectroscopy, test–retest, Humans, Reproducibility of Results, Male, Female, Adult, Magnetic Resonance Imaging, Gray Matter, Signal-To-Noise Ratio, Magnetic Resonance Spectroscopy, Brain, White Matter, Young Adult