Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Dynamic control of protein phosphorylation is necessary for the regulation of many cellular processes, including mitosis and cytokinesis. Indeed, although the central role of protein kinases is widely appreciated and intensely studied, the importance of protein phosphatases is often overlooked. Recent studies, however, have highlighted the considerable role of protein phosphatases in both the spatial and temporal control of protein kinase activity, and the modulation of substrate phosphorylation. Here, we will focus on recent advances in our understanding of phosphatase structure, and the importance of phosphatase function in the control of mitotic spindle formation, chromosome architecture and cohesion, and cell division.

Original publication

DOI

10.1242/jcs.087106

Type

Journal article

Journal

J Cell Sci

Publication Date

15/07/2011

Volume

124

Pages

2323 - 2334

Keywords

Animals, Humans, Mice, Mitosis, Phosphoprotein Phosphatases, Protein Processing, Post-Translational, Spindle Apparatus