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The effects of ten once-daily injections of desmethylimipramine (10 mg/kg i.p.) on alpha 2- and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus and hypothalamus. [3H]clonidine and [3H]dihydroalprenolol were used as ligands for alpha 2- and beta-adrenoceptors, respectively. Twenty-four hours after the last injection, the density of beta-adrenoceptors was reduced in all regions studied. In contrast, there was no change in alpha 2-adrenoceptor binding in the cortex, while increased binding was found in the hypothalamus. The effects of desmethylimipramine are discussed in relation to those of other antidepressant treatments.


Journal article



Publication Date





161 - 164


Animals, Brain, Cerebral Cortex, Desipramine, Hippocampus, Hypothalamus, Male, Rats, Rats, Inbred Strains, Receptors, Adrenergic, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta