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The effect of the 5-HT3 receptor antagonist, ondansetron, on the decrease in hunger produced by amphetamine was assessed in nine male volunteers using a double-blind cross-over design. Amphetamine (15 mg orally) produced a significant decrease in self-ratings of hunger 2.5 h after administration. This effect was significantly attenuated by pre-treatment with ondansetron (12 mg orally over 24 h). These findings in humans are consistent with data from animal studies suggesting that ondansetron can attenuate certain catecholamins-mediated behaviours produced by amphetamine. However, explanations founded on pharmacokinetic factors cannot be presently excluded.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1992

Volume

107

Pages

140 - 141

Keywords

Adult, Amphetamine, Behavior, Humans, Hunger, Imidazoles, Male, Middle Aged, Ondansetron, Reference Values, Serotonin Antagonists