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A number of rat monoclonal antibodies of the IgG2b subclass have been used to deplete mice of T lymphocyte subsets. It has been possible to produce long-term depletion where antibodies are administered to mice thymectomized in their adult life, or short-term depletion in euthymic animals. It is therefore feasible to ablate a T lymphocyte subpopulation at any stage in the course of an immune response and to examine in detail the role of a particular subset in the induction or effector phases of that response. We have used such ablative procedures to define the T cell subsets which participate in graft rejection, graft-versus-host disease, antigenic competition and antiviral and anti-self immunity and have attempted to exploit such knowledge to establish immunological tolerance in an adult animal.

Type

Journal article

Journal

Ciba Found Symp

Publication Date

1987

Volume

129

Pages

194 - 208

Keywords

Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, Antigens, Ly, Graft Rejection, Graft vs Host Disease, Lymphocyte Depletion, Mice, Mice, Inbred Strains, T-Lymphocytes