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Nikkomycin was found to be a potent growth inhibitor of Candida albicans through competitive inhibition of chitin synthase [Ki = 0.16 microM (0.1 microgram ml-1)]. The activity of the peptide-nucleoside drug was antagonized by both peptone and defined peptides. Transported dipeptides were effective antagonists while transported oligopeptides were not. A mutant of C. albicans resistant to the effects of nikkomycin through a transport defect was unable to transport dipeptides, while oligopeptide uptake was apparently unaffected. At least two peptide permeases are operational in this organism.

Original publication

DOI

10.1099/00221287-131-4-775

Type

Journal article

Journal

J Gen Microbiol

Publication Date

04/1985

Volume

131

Pages

775 - 780

Keywords

Aminoglycosides, Anti-Bacterial Agents, Antifungal Agents, Biological Transport, Candida albicans, Chitin Synthase, Nucleosides, Peptides