Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Patients with autoantibodies which target neuronal proteins can have pain as an under-recognised clinical manifestation.

Patients with autoantibodies which target neuronal proteins can have pain as an under-recognised clinical manifestation.

In a new study, four research groups within the Nuffield Department of Clinical Neurosciences combine their strengths in autoimmunity (Irani), pain (Bennett and Dawes) and peripheral nerve diseases (Rinaldi).

Their collective findings reveal that patients with antibodies to LGI1 and CASPR2 show different clinical, immunological and neurobiological characteristics which may relate to the antibodies differentially targeting neurons which can mediate pain.

The findings have implications for improving the long-term outcomes of these patients and for our understanding of the basic biology of these antigenic targets.

Read the paper

Similar stories

New insights into the effect of exposure to dim light in the evening on the biology of the sleep-wake cycle

A new study has revealed more about how exposure to dim light in the evening affects circadian health. The findings emphasise the need to optimise our artificial light exposure if we are to avoid shifting our biological clocks.

Blood lipoprotein levels linked to future risk of amyotrophic lateral sclerosis

Greater understanding of the role of lipoproteins could support screening and efforts to develop treatments.

Improved Risk Estimation of Bipolar Spectrum Disorders in Adolescent Offspring of Bipolar Parents

This new study using Canadian and Swiss data showed that the risk calculator used to predict the likelihood of developing a major mood disorder was correct approximately 70% of the time. The study results suggest this may be a useful clinical tool in routine practice for improved individualised risk estimation of bipolar spectrum disorders among the adolescent offspring of a parent with a bipolar disorder.

Understanding the mechanisms involved in Alzheimer's disease

A new study from the Department of Pharmacology sheds light on the link between the two major Alzheimer's disease pathologies.