I studied Medicine at the University of Birmingham (1991-97) and continued my general medical training in Oxford. I then spent three years working on the genetic linkage and association of neurological disorders at the Wellcome Trust Centre for Human Genetics. After obtaining my DPhil in 2003, I completed my training in Clinical Neurology at Oxford. I joined the Department of Physiology, Anatomy and Genetics in 2007 after being awarded an MRC Clinician Scientist Fellowship to establish my own research group. I then led IMI StemBANCC - an large public-private partnerhsip funded by the EU to establish iPSC resources for academia and industry across europe.
I now lead IMI IM2PACT which is an amibitious research programme to investigate disease mechanism involving the brain neurovascular unit and find transport mechanisms to get therapeutics into the brain.
My research group aims to develop resources and tools to improve drug discovery by leveraging human data and human iPSC brain models. We work on pain/migraine, Alzheimer's disease and autism/epilepsy.
I am also active clinically and work as a Consultant Neurologist at the John Radcliffe Hospital with an interest in Headache Disorders. I am Director of the Oxford Headache Centre and developed the Oxford Community Headache Service.
Director of the Oxford Headache Centre and Director of StemBANCC
- Professor of Neuroscience and Neurology
- Consultant Neurologist
Molecular disease mechanisms and cellular disease phenotypes in neurological disorders
The Translational Molecular Neuroscience Group looks at neurogenetic disorders, often rare variants of common disease. Understanding the disease pathways in these conditions will allow development of meaningful therapies. The group is developing new disease models for more effective drug discovery platforms.
Sources of Funding
- EU FP7
- Wellcome Trust
- NIHR BRC
- Medical Research Council
- John Fell
Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories.
Pokhilko A. et al, (2021), Genome Res, 31, 1069 - 1081
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease.
Pokhilko A. et al, (2021), J Cereb Blood Flow Metab
TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses.
Lalic T. et al, (2020), Nat Commun, 11
Targeted RNA sequencing enhances gene expression profiling of ultra-low input samples
CADER M. et al, (2020), RNA Biology
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder.
Sanghani HR. et al, (2020), Mol Psychiatry