MRC Career Development Fellow
Dr. Ellender’s group is examining the genetic and activity dependent rules that govern the development of the basal ganglia circuitry. The group’s work combines electrophysiological recordings of multiple neurons in vitroand in vivo in combination with optogenetic and pharmacogenetic techniques to both observe and manipulate neural activity and circuit development.
Key research areas:
- Development of the striatal neural circuitry.
- Neuromodulation of striatal circuit function.
- Cellular mechanisms underlying the generation of physiological and pathological neural network activity
Our current research efforts are focused on defining the early developmental processes controlling the formation of the striatum, with the aim of generating rationale and identifying targets for intervention in a range of neurodevelopmental disorders involving the basal ganglia.
Sources of Funding
- MRC 2015- 2020
Dr. Tommas Ellender completed his D.Phil. in Integrative Physiology at the University of Oxford in 2009 under the supervision of Professor Ole Paulsen. He was then recruited as a postdoctoral fellow to work with Professor Paul Bolam in Oxford studying the complex circuitry of the basal ganglia. In 2010, Tommas was elected as a Biomedical Junior Research Fellow at Linacre College, Oxford. In 2012, he moved to the Department of Pharmacology to undertake postdoctoral work with Colin Akerman, where his research focused on the developmental processes underlying the construction of neural circuits. He concurrently held a Research Associate position at Corpus Christi College, Oxford.
In 2015, Tommas was awarded a MRC Career Development Award, enabling him to pursue an independent research programme at the Department of Pharmacology.