Natalia Gromak

• Increased global transcription activity as a mechanism of replication stress in cancer.

  Kotsantis P. et al, (2016), Nat Commun, 7

• Out of balance: R-loops in human disease.

  Groh M. and Gromak N., (2014), PLoS Genet, 10

• Mechanisms of transcriptional dysregulation in repeat expansion disorders.

  Groh M. et al, (2014), Biochem Soc Trans, 42, 1123 - 1128

• R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.

  Groh M. et al, (2014), PLoS Genet, 10

• Drosha regulates gene expression independently of RNA cleavage function.

  Gromak N. et al, (2013), Cell Rep, 5, 1499 - 1510

• Intronic microRNAs: a crossroad in gene regulation.

  Gromak N., (2012), Biochem Soc Trans, 40, 759 - 761

• Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.

  Skourti-Stathaki K. et al, (2011), Mol Cell, 42, 794 - 805

• Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

  Webby CJ. et al, (2009), Science, 325, 90 - 93

• Primary microRNA transcripts are processed co-transcriptionally.

  Morlando M. et al, (2008), Nat Struct Mol Biol, 15, 902 - 909

• Primary microRNA transcripts are processed co-transcriptionally.

  Morlando M. et al, (2008), Nat Struct Mol Biol

• Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.

  Gromak N. et al, (2008), RNA, 14, 359 - 366

• Pause sites promote transcriptional termination of mammalian RNA polymerase II.

  Gromak N. et al, (2006), Mol Cell Biol, 26, 3986 - 3996

• Exon tethering in transcription by RNA polymerase II.

  Dye MJ. et al, (2006), Mol Cell, 21, 849 - 859

• Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.

  West S. et al, (2006), Mol Cell, 21, 437 - 443

• Turnover and function of noncoding RNA polymerase II transcripts.

  Dye MJ. et al, (2006), Cold Spring Harb Symp Quant Biol, 71, 275 - 284

• Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.

  West S. et al, (2004), Nature, 432, 522 - 525

• The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing.

  Gromak N. et al, (2003), EMBO J, 22, 6356 - 6364

• Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein.

  Gromak N. et al, (2003), RNA, 9, 443 - 456

• A splicing silencer that regulates smooth muscle specific alternative splicing is active in multiple cell types.

  Gromak N. and Smith CW., (2002), Nucleic Acids Res, 30, 3548 - 3557

Recent Publications

• Increased global transcription activity as a mechanism of replication stress in cancer.

  Kotsantis P. et al, (2016), Nat Commun, 7

• Out of balance: R-loops in human disease.

  Groh M. and Gromak N., (2014), PLoS Genet, 10

• Mechanisms of transcriptional dysregulation in repeat expansion disorders.

  Groh M. et al, (2014), Biochem Soc Trans, 42, 1123 - 1128

• R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.

  Groh M. et al, (2014), PLoS Genet, 10

• Drosha regulates gene expression independently of RNA cleavage function.

  Gromak N. et al, (2013), Cell Rep, 5, 1499 - 1510