Research groups
Colleges
Websites
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Laboratory for Cognitive Brain Mapping; RIKEN Brain Science Institute, Japan
Visiting Scientist
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Tohoku University Brain Science Center, Japan
Visiting Professor
Mark J. Buckley
MA DPhil
Professor of Behavioural and Cognitive Neuroscience
- Fellow of The Queen's College
Research Summary
I head the Brain and Behaviour Research Group in which we conduct basic neuroscience research to determine how neural systems underlie behaviour and cognition. Applied research aimed at relieving debilitating brain disease and disorders (e.g. dementias, amnesias, Schizophrenia, mood disorders etc.) depends crucially on basic research advancing understanding of how normal neural activity underlies normal behaviour, in addition to understanding why abnormal and dysfunctional behaviour may occur when these brain networks are compromised. For example, we have long been interested in understanding how brain areas in the temporal lobes and in associated regions, some of which become dysfunction in dementias including Alzheimer’s Disease, operate in mediating perception and memory. Likewise we have also focused our attention on understanding how more anterior brain regions in the frontal lobes operate in mediating learning and memory as well as other key elements of cognition including choice behaviour and goal-directed behaviour. An overarching theme of the current research in my laboratory is to progress beyond the traditional focus of research on individual regions and move to an understanding of how networks of interconnected brain regions interact together to mediate normal learning, memory and cognition. To do this we have to investigate both normal and abnormal brain function using a range of complementary neuropsychological, neurophysiological, and neuroimaging techniques. Our work is funded by the MRC, BBSRC, and Wellcome Trust.
Key publications
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Managing competing goals - a key role for the frontopolar cortex.
Journal article
Mansouri FA. et al, (2017), Nat Rev Neurosci, 18, 645 - 657
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Conflict-induced behavioural adjustment: a clue to the executive functions of the prefrontal cortex.
Journal article
Mansouri FA. et al, (2009), Nat Rev Neurosci, 10, 141 - 152
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Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions.
Journal article
Buckley MJ. et al, (2009), Science, 325, 52 - 58
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Mnemonic function of the dorsolateral prefrontal cortex in conflict-induced behavioral adjustment.
Journal article
Mansouri FA. et al, (2007), Science, 318, 987 - 990
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A role for the macaque anterior cingulate gyrus in social valuation.
Journal article
Rudebeck PH. et al, (2006), Science, 313, 1310 - 1312
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Essential functions of primate frontopolar cortex in cognition.
Journal article
Boschin EA. et al, (2015), Proc Natl Acad Sci U S A, 112, E1020 - E1027
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Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices.
Journal article
Mansouri FA. et al, (2015), Proc Natl Acad Sci U S A, 112, E3940 - E3949
Recent publications
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Disentangling frontal-striatal contributions to exploration
Journal article
Ainsworth M. and Buckley MJ., (2025), Neuron, 113, 2554 - 2555
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Memories or decisions? Bridging accounts of frontopolar function.
Journal article
Boschin EA. et al, (2025), Neuropsychologia, 211
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Effects of noise and metabolic cost on cortical task representations.
Journal article
Stroud JP. et al, (2025), Elife, 13
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Tracking subjects' strategies in behavioural choice experiments at trial resolution.
Journal article
Maggi S. et al, (2024), Elife, 13
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Title Mapping causal links between prefrontal cortical regions and intra-individual behavioral variability
Journal article
Mansouri F. et al, (2024), Nature Communications
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Frontal and temporal coding dynamics in successive steps of complex behavior.
Journal article
Kadohisa M. et al, (2022), Neuron
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Low beta repetitive transcranial magnetic stimulation to human dorsolateral prefrontal cortex during object recognition memory sample presentation, at a task related frequency observed in local field potentials in homologous macaque cortex, impairs subsequent recollection but not familiarity.
Journal article
Wu Z. et al, (2021), Eur J Neurosci
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A one-shot shift from explore to exploit in monkey prefrontal cortex
Journal article
Achterberg J. et al, (2021), The Journal of Neuroscience
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Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques.
Journal article
Sallet J. et al, (2020), PLoS Biol, 18
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Focused Representation of Successive Task Episodes in Frontal and Parietal Cortex.
Journal article
Kadohisa M. et al, (2019), Cereb Cortex
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Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex.
Journal article
Bridge H. et al, (2019), Elife, 8
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Context-Dependent Adjustments in Executive Control of Goal-Directed Behaviour: Contribution of Frontal Brain Areas to Conflict-Induced Behavioural Adjustments in Primates
Chapter
Mansouri FA. and BUCKLEY MJ., (2018), Systems Neuroscience., 21
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Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.
Journal article
Browncross H. et al, (2018), Neuropsychologia
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Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.
Journal article
Ainsworth M. et al, (2018), Neuropsychologia, 119, 382 - 391
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Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.
Journal article
Ainsworth M. et al, (2018), Neuropsychologia, 119, 382 - 391
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Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys
Journal article
Browncross H. et al, (2018), Neuropsychologia
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A new approach to solving the feature-binding problem in primate vision.
Journal article
Isbister JB. et al, (2018), Interface Focus, 8
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Inverted activity patterns in ventromedial prefrontal cortex during value-guided decision-making in a less-is-more task.
Journal article
Papageorgiou GK. et al, (2017), Nat Commun, 8
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Managing competing goals - a key role for the frontopolar cortex.
Journal article
Mansouri FA. et al, (2017), Nat Rev Neurosci, 18, 645 - 657
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Transcranial magnetic stimulation to dorsolateral prefrontal cortex affects conflict-induced behavioural adaptation in a Wisconsin Card Sorting Test analogue.
Journal article
Boschin EA. et al, (2017), Neuropsychologia, 94, 36 - 43