Ivan Koychev
PhD MRCPsych
Senior Clinical Researcher
- Clinician Scientist Dementias Platform UK
- Consultant Neuropsychiatrist Oxford University Hospitals NHS Foundation Trust
I am a clinical academic psychiatrist (on the GMC Specialist Register for Old Age and General Adult Psychiatry) with a focus on the development of treatments for neuropsychiatric disorders. My research spans the key components of neuroscience clinical trial methodology: conduct of proof-of-concept (PoC) biomarker-based clinical trials in surrogate populations, testing of repurposed compounds, development of stratification and efficacy biomarkers and creation of infrastructure for large-scale stratified recruitment into neuroscience experimental medicine studies and clinical trials. Clinically, I focus on the assessment and management of patients with neuropsychiatric presentations in acute medical settings.
Key publications
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PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers.
Journal article
Koychev I. et al, (2017), J Alzheimers Dis, 60, 283 - 293
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Blood-based ATN biomarkers of Alzheimer’s disease: A meta-analysis
Journal article
KOYCHEV I. et al, (2020), Journal of Alzheimer's Disease
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Deep and Frequent Phenotyping study protocol: an observational study in prodromal Alzheimer's disease.
Journal article
Koychev I. et al, (2019), BMJ Open, 9
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Prediction of Alzheimer's disease biomarker status defined by the 'ATN framework' among cognitively healthy individuals: results from the EPAD longitudinal cohort study.
Journal article
Calvin CM. et al, (2020), Alzheimers Res Ther, 12
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Real-world effectiveness, its predictors and onset of action of cholinesterase inhibitors and memantine in dementia: retrospective health record study.
Journal article
Vaci N. et al, (2020), Br J Psychiatry, 1 - 7
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Dementias Platform UK Clinical Studies and Great Minds Register: protocol of a targeted brain health studies recontact database.
Journal article
Koychev I. et al, (2020), BMJ Open, 10
Recent publications
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Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model.
Journal article
Liu Q. et al, (2022), BMC Med, 20
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Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study
Journal article
Dounavi ME. et al, (2022), Journal of Neurology
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Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis
Journal article
KOYCHEV I. et al, (2021), Brain Communications
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Secondary prevention of dementia: Combining risk factors and scalable screening technology
Journal article
KOYCHEV I. and Ojakäär T., (2021), Frontiers in Neurology
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An Investigation of Levetiracetam in Alzheimer's Disease (ILiAD): a double-blind, placebo-controlled, randomised crossover proof of concept study.
Journal article
Sen A. et al, (2021), Trials, 22