Head of Department
- Professor of Biochemistry and Pharmacology
Professor Platt obtained a BSc in Zoology at Imperial College University of London and a PhD in animal physiology from the University of Bath. She was a post-doctoral fellow at Washington University Medical School in St Louis, USA. She returned to the UK in 1989 (to the Biochemistry Department, University of Oxford) where she focused on how the abnormal accumulation of glycosphingolipids results in pathology in lysosomal storage diseases.
She was a Lister Institute Senior Research Fellow from 1996-2002. A major focus of her work has been on the development of substrate reduction therapy (SRT) to treat several of these disorders. Proof of principle of SRT was demonstrated in mouse models of these primarily neurodegenerative diseases. Dr Platt’s research, in collaboration with Dr Terry Butters, has led to the development of the approved drug miglustat/Zavesca for glycosphingolipid storage disease therapy.
Her current interests focus on the cell biology and pathobiology of glycosphingolipids and on the development of novel therapies for treating diseases resulting from defects in gycolipid metabolism and lysosomal dysfunction.
She moved to the Department of Pharmacology in April 2006 and was elected a fellow of the Academy of Medical Sciences in 2011.
Key Research Areas:
- Lysosomal storage disorders, pathogenesis and therapy
- The effects of lysosomal storage on the immune system
- Development of biomarkers for monitoring storage disease patients
- Lysosomal dysfunction in more common diseases
Identification of genetic modifiers of murine hepatic β-glucocerebrosidase activity.
Durán A. et al, (2021), Biochem Biophys Rep, 28
VESICLE CHOLESTEROL CONTROLS EXOCYTOTIC FUSION PORE
PLATT F. and Frances P., (2021), Cell Calcium
International consensus on clinical severity scale use in evaluating Niemann-Pick disease Type C in paediatric and adult patients: results from a Delphi Study
PLATT F., (2021), Orphanet Journal of Rare Diseases
Glycosphingolipid metabolism and its role in ageing and Parkinson's disease.
Wallom K-L. et al, (2021), Glycoconj J
A modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue.
Ayagama T. et al, (2021), iScience, 24
Acetylation turns leucine into a drug by membrane transporter switching.
Churchill GC. et al, (2021), Sci Rep, 11
Transcriptome of HPβCD-treated Niemann-pick disease type C1 cells highlights GPNMB as a biomarker for therapeutics.
Rodriguez-Gil JL. et al, (2021), Hum Mol Genet