DBE, FRS, FMedSci
Frances Ashcroft held the title of Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology, Oxford and is a Fellow of Trinity College, Oxford. She holds BA, PhD and ScD degrees from Cambridge University and was elected a Fellow of the Royal Society of London in 1999. Her research focuses on ATP-sensitive potassium (KATP) channels and their role in insulin secretion, in both health and disease. She is interested in how KATP channel function relates to channel structure, how cell metabolism regulates channel activity, and how mutations in KATP channel genes cause human disease. The ultimate goal is to elucidate how a rise in the blood glucose concentration stimulates the release of insulin from the pancreatic beta-cells, what goes wrong with this process in type 2 diabetes, and how drugs used to treat this condition exert their beneficial effects. She has written a text book "Ion Channels and Disease" and is Director of OXION, a training and research programme on the integrative physiology of ion channels, funded by the Wellcome Trust.
KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture
Ashcroft FM., (2023), Diabetes, 72, 693 - 702
Glucokinase activity in diabetes: too much of a good thing?
Ashcroft FM. et al, (2022), Trends Endocrinol Metab
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
Haythorne E. et al, (2022), Nat Commun, 13
The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel.
Pipatpolkai T. et al, (2022), J Physiol
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate.
Koberstein JN. et al, (2022), Proc Natl Acad Sci U S A, 119