- Neural Injury Group Research Group
Peripheral entrapment neuropathies such as carpal tunnel syndrome or radiculopathies are common conditions that are caused by compression of a nerve as it travels through narrow anatomical spaces. Symptoms include tingling, numbness and weakness and are classically restricted to the affected nerve territory (e.g. the hand in carpal tunnel syndrome). Some patients however develop chronic neuropathic pain, which may even spread beyond the lesion site. The exact pathophysiology underlying compression neuropathies and why a subgroup of patients develops debilitating neuropathic pain is still unknown.
My research focusses on advancing our understanding of the pathophysiology of compression neuropathies to ultimately improve management of these patients.
Local and remote immune-mediated inflammation after mild peripheral nerve compression in rats.
Schmid AB. et al, (2013), J Neuropathol Exp Neurol, 72, 662 - 680
Reappraising entrapment neuropathies--mechanisms, diagnosis and management.
Schmid AB. et al, (2013), Man Ther, 18, 449 - 457
Negative Neurodynamic Tests Do Not Exclude Neural Dysfunction in Patients With Entrapment Neuropathies.
Baselgia LT. et al, (2017), Arch Phys Med Rehabil, 98, 480 - 486
Education, night splinting and exercise versus usual care on recovery and conversion to surgery for people awaiting carpal tunnel surgery: a protocol for a randomised controlled trial.
Lewis KJ. et al, (2016), BMJ Open, 6
Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but not Cytokine and Muscle Fiber Changes.
James G. et al, (2016), Spine (Phila Pa 1976), 41, 1208 - 1217
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury.
Calvo M. et al, (2016), Elife, 5
Multifidus Muscle Changes After Back Injury Are Characterized by Structural Remodeling of Muscle, Adipose and Connective Tissue, but Not Muscle Atrophy: Molecular and Morphological Evidence.
Hodges PW. et al, (2015), Spine (Phila Pa 1976), 40, 1057 - 1071