Contact information
01865 223254
Research groups
Colleges
Annina Schmid
MMACP, MManipTher, PhD
Professor of Pain Neurosciences
- Head, Neuromusculoskeletal Health and Science Lab
- Wellcome Clinical Career Development Fellow
- BRC Senior Research Fellow
- Specialist Musculoskeletal Physiotherapist MMACP
- Governing Body Fellow Wolfson College
Research focus
Peripheral entrapment neuropathies such as carpal tunnel syndrome or radiculopathies are common conditions that are caused by compression of a nerve as it travels through narrow anatomical spaces. Symptoms include tingling, numbness and weakness and many patients develop neuropathic pain. The first-line treatment for entrapment neuropathies is non-surgical management including physiotherapy and pharmacology. However, the effects of non-surgical management are often modest. A major road-block to delivering more effective interventions is a lack of understanding of disease mechanisms resulting in inadequate patient stratification.
My research focusses on advancing our understanding of the pathophysiology of entrapment neuropathies with the ultimate aim to develop precision physiotherapy and improve management for these patients.
My group uses entrapment neuropathies as unique model systems that allow the prospective evaluation of nerve injury and repair in the context of neuropathic pain. We use a range of methodologies including deep clinical phenotyping with quantitative sensory testing and neurophysiological methods. I have also been at the forefront in developing advanced neuroimaging methods to visualise peripheral nerves at ultra-high field strength (MR neurography). In addition, we use a range of technologies (e.g., RNA sequencing, qPCR, specialised histology) to study the cellular and molecular aspects of entrapment neuropathies. This multimodal and innovative approach allows a detailed understanding of the mechanisms underlying entrapment neuropathies and neuropathic pain in general.
If you are interested in doing a PhD/DPhil with my team, please get in touch.
Websites
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Neuromusculoskeletal Health and Science Lab
have a look at my group's website
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www.neuro-research.ch
Here you can find more information about my background, academic, clinical and teaching work
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Why you cannot trust the dermatomes
Please see our recent animated video explaining why you cannot trust the dermatomes
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What is sciatica?
Have a look at our short video explaining what 'sciatica' is for patients
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Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth
Here you can see our video summary explaining our findings on a gene related to human nerve regeneration
Key publications
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Journal article
Baskozos G. et al, (2020), Brain, 143, 2009 - 2026
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Journal article
Lewis KJ. et al, (2020), J Physiother, 66, 97 - 104
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Journal article
Schmid AB. et al, (2014), Brain, 137, 3186 - 3199
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Journal article
Wiberg A. et al, (2019), Nat Commun, 10
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Journal article
Schmid AB. et al, (2018), Invest Radiol, 53, 705 - 713
Recent publications
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Individual endogenous pain modulation profiles within a multidimensional context of people with cervicogenic headache - A retrospective exploratory study.
Journal article
Mingels S. et al, (2023), Musculoskelet Sci Pract, 67
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Inter- and intra-rater-reliability of a clinical framework for spine-related neck-arm pain.
Journal article
Kapitza C. et al, (2023), Musculoskelet Sci Pract, 67
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Early surgery for sciatica.
Journal article
Schmid AB. et al, (2023), BMJ, 381
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Factors predicting the transition from acute to persistent pain in people with 'sciatica': the FORECAST longitudinal prognostic factor cohort study protocol.
Journal article
Schmid AB. et al, (2023), BMJ Open, 13
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RECOMMENDATIONS FOR TERMINOLOGY AND THE IDENTIFICATION OF NEUROPATHIC PAIN IN PEOPLE WITH SPINE-RELATED LEG PAIN. OUTCOMES FROM THE NEUPSIG WORKING GROUP
Journal article
SCHMID A., (2023), Pain