Research groups
Alun Barnard
BSc PhD
Senior Postdoctoral Research Scientist
After completing a BSc in Biology at Imperial College London, Alun gained a PhD in Neuroscience from the Faculty of Life Sciences, University of Manchester. Following a career development fellowship at the Mammalian Genetics Unit, MRC Harwell, he joined the University of Oxford in 2009. Currently he is a Senior Postdoctoral Researcher in a group dedicated to finding new treatments for blindness, particularly in patients with incurable retinal diseases, through clinical and laboratory research.
Key publications
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Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.
Journal article
MacLaren RE. et al, (2014), Lancet, 383, 1129 - 1137
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Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo
Journal article
Tolmachova T. et al, (2013), Journal of Molecular Medicine, 91, 825 - 837
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Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
Journal article
Singh MS. et al, (2013), Proc Natl Acad Sci U S A, 110, 1101 - 1106
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Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy.
Journal article
Barnard AR. et al, (2011), Exp Eye Res, 93, 771 - 777
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Melanopsin regulates visual processing in the mouse retina.
Journal article
Barnard AR. et al, (2006), Curr Biol, 16, 389 - 395
Recent publications
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The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.
Journal article
Cross SH. et al, (2020), PLoS Genet, 16
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Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues.
Journal article
Chandler LC. et al, (2019), Mol Ther Methods Clin Dev, 14, 77 - 89
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Filtration of Short-Wavelength Light Provides Therapeutic Benefit in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation.
Journal article
Orlans HO. et al, (2019), Invest Ophthalmol Vis Sci, 60, 2733 - 2742
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Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia.
Journal article
Xue K. et al, (2018), Nat Med, 24, 1507 - 1512
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Differential roles for cryptochromes in the mammalian retinal clock.
Journal article
Wong JCY. et al, (2018), FASEB J, 32, 4302 - 4314