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The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.

Original publication

DOI

10.1038/nature05818

Type

Journal article

Journal

Nature

Publication Date

26/04/2007

Volume

446

Pages

1038 - 1045

Keywords

AIDS Vaccines, Animals, Anti-HIV Agents, Carbohydrates, Drug Design, HIV Antigens, HIV-1, Humans