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Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.

Original publication

DOI

10.1038/nsmb1204

Type

Journal article

Journal

Nat Struct Mol Biol

Publication Date

03/2007

Volume

14

Pages

243 - 245

Keywords

Gene Silencing, Histone-Lysine N-Methyltransferase, Histones, Jumonji Domain-Containing Histone Demethylases, Lysine, Oxidoreductases, O-Demethylating, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Telomere