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Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.

Original publication

DOI

10.1038/nsmb1216

Type

Journal article

Journal

Nat Struct Mol Biol

Publication Date

04/2007

Volume

14

Pages

341 - 343

Keywords

Animals, DNA-Binding Proteins, Drosophila Proteins, Drosophila melanogaster, Histone Demethylases, Histone-Lysine N-Methyltransferase, Histones, Larva, Lysine, Methylation, Mutant Proteins, Protein Structure, Tertiary, Protein Transport, RNA Polymerase II, Substrate Specificity, Transcription Factors