Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The two mating type loci MATa and MAT alpha each produce two mRNAs that are transcribed in opposite and diverging directions from central promoters. Silent copies of MATa (HMRa) and MAT alpha (HML alpha) contain identical DNA sequences throughout the transcribed region, yet are not transcribed. It is concluded that sequences to the left of HMRa (and probably HML alpha) must somehow affect transcription initiated at the centre of each locus 700 to 1,400 base pairs away. A possible mechanism for this position effect is discussed.

Type

Journal article

Journal

Nature

Publication Date

22/01/1981

Volume

289

Pages

244 - 250

Keywords

Base Sequence, DNA Transposable Elements, DNA, Fungal, Gene Expression Regulation, Genetic Linkage, RNA, Fungal, Reproduction, Saccharomyces cerevisiae, Transcription, Genetic