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The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.

Original publication

DOI

10.1098/rstb.2004.1604

Type

Journal article

Journal

Philos Trans R Soc Lond B Biol Sci

Publication Date

29/03/2005

Volume

360

Pages

483 - 496

Keywords

Adenosine Triphosphate, Cell Cycle, Cell Cycle Proteins, Chromatids, Chromosomal Proteins, Non-Histone, Fungal Proteins, Models, Biological, Nuclear Proteins, Protein Conformation, Spindle Apparatus