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The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

Original publication

DOI

10.1146/annurev-genet-102108-134233

Type

Journal article

Journal

Annu Rev Genet

Publication Date

2009

Volume

43

Pages

525 - 558

Keywords

Animals, Cell Cycle Proteins, Chromosomal Proteins, Non-Histone, Chromosomes, DNA, Humans, Models, Biological