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Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR interval). In the current study, we meta-analyzed genome-wide association results from 30,000 mostly Dutch samples on four ECG traits: PR interval, QRS duration, QT interval, and RR interval. SNP genotype data was imputed using the Genome of the Netherlands reference panel encompassing 19 million SNPs, including millions of rare SNPs (minor allele frequency 

Original publication

DOI

10.1038/s41431-018-0295-z

Type

Journal article

Journal

Eur J Hum Genet

Publication Date

06/2019

Volume

27

Pages

952 - 962

Keywords

Electrocardiography, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Netherlands, Polymorphism, Single Nucleotide