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In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.

Original publication

DOI

10.1038/nri840

Type

Journal article

Journal

Nat Rev Immunol

Publication Date

07/2002

Volume

2

Pages

476 - 486

Keywords

Animals, Cell Cycle Proteins, Humans, Lymphocytes, Models, Biological, Protein Binding, Protein Conformation, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Receptors, Immunologic, Signal Transduction, Structure-Activity Relationship