Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Sequence-specific RNA binding proteins (RBP) are important regulators of the immune response. RBP modulate gene expression by regulating splicing, polyadenylation, localization, translation and decay of target mRNAs. Increasing evidence suggests that RBP play critical roles in the development, activation and function of lymphocyte populations in the immune system. This review will discuss the post-transcriptional regulation of gene expression by RBP during lymphocyte development, with particular focus on the Tristetraprolin family of RBP.

Original publication

DOI

10.1111/cei.12684

Type

Journal article

Journal

Clin Exp Immunol

Publication Date

01/2016

Volume

183

Pages

37 - 49

Keywords

cell activation, gene regulation, inflammation, Animals, Cell Differentiation, Gene Expression Regulation, Humans, Lymphocyte Activation, Lymphocytes, RNA Processing, Post-Transcriptional, RNA, Messenger, RNA-Binding Proteins, Tristetraprolin