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Cognitive functions are important correlates of health outcomes across the life-course. Individual differences in cognitive functions are partly heritable. Epigenetic modifications, such as DNA methylation, are susceptible to both genetic and environmental factors and may provide insights into individual differences in cognitive functions. Epigenome-wide meta-analyses for blood-based DNA methylation levels at ~420,000 CpG sites were performed for seven measures of cognitive functioning using data from 11 cohorts. CpGs that passed a Bonferroni correction, adjusting for the number of CpGs and cognitive tests, were assessed for: longitudinal change; being under genetic control (methylation QTLs); and associations with brain health (structural MRI), brain methylation and Alzheimer's disease pathology. Across the seven measures of cognitive functioning (meta-analysis n range: 2557-6809), there were epigenome-wide significant (P 

Original publication

DOI

10.1038/s41380-017-0008-y

Type

Journal article

Journal

Mol Psychiatry

Publication Date

11/2018

Volume

23

Pages

2133 - 2144

Keywords

Adult, Aged, Aged, 80 and over, Cognition, Cohort Studies, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Genome-Wide Association Study, Genomics, Humans, Male, Middle Aged