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Here we investigated the effect of naloxone-precipitated morphine withdrawal on the release of noradrenaline in hippocampus of the anaesthetised rat. Naloxone (1 mg/kg i.p.) injected 3 and 24 h, but not 3 weeks, after eight daily injections of morphine, induced an immediate increase in hippocampal noradrenaline release. This striking effect of naloxone was markedly attenuated by pretreatment with clonidine (0.1 mg/kg s.c.). These findings provide direct evidence for a marked release of noradrenaline in hippocampus during opiate withdrawal in vivo.


Journal article


Eur J Pharmacol

Publication Date





333 - 336


Animals, Chromatography, High Pressure Liquid, Clonidine, Dialysis, Electrochemistry, Hippocampus, Locus Coeruleus, Male, Morphine, Naloxone, Norepinephrine, Rats, Rats, Sprague-Dawley, Substance Withdrawal Syndrome, Substance-Related Disorders