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We studied the effects of haloperidol (0.5 mg, intravenously) on latent inhibition in an auditory paradigm and two visual paradigms in healthy subjects. Haloperidol increased latent inhibition in one visual paradigm and tended to increase latent inhibition in an auditory task, compared to saline-injected controls. These results indicate that haloperidol can enhance the selectivity of attention. In contrast, previous studies have reported that acute schizophrenics show reduced latent inhibition.

Original publication




Journal article


Biol Psychiatry

Publication Date





1135 - 1143


Acoustic Stimulation, Antipsychotic Agents, Attention, Conditioning, Operant, Double-Blind Method, Haloperidol, Humans, Injections, Intravenous, Models, Psychological, Photic Stimulation, Reaction Time, Reflex, Startle, Schizophrenic Psychology