Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The distribution of neurotransmitter receptors over the neuronal cell surface remains an outstanding question in neurobiology. In this study we have used autoradiographic procedures to localize muscarinic receptors on living cultures of enteric neurons, using the specific irreversible muscarinic ligand, [3H]propylbenzilylcholine mustard ([3H]PrBCM). Most of the label was associated with nerve processes surrounding the cell bodies and along the lengths of many of the neurites radiating from the cell bodies; a small proportion of the nerve cell bodies was also seen to be labeled. The distribution of autoradiograph silver grains along both varicose and non-varicose neurites demonstrated that muscarinic receptors were present on both pre-terminal and terminal regions of the nerve fibres.

Type

Journal article

Journal

Brain Res

Publication Date

17/09/1984

Volume

310

Pages

133 - 137

Keywords

Animals, Animals, Newborn, Autoradiography, Cell Membrane, Culture Techniques, Guinea Pigs, Myenteric Plexus, Propylbenzilylcholine Mustard, Receptors, Muscarinic