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The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection.

Original publication

DOI

10.1016/j.chom.2018.06.008

Type

Journal article

Journal

Cell Host Microbe

Publication Date

11/07/2018

Volume

24

Pages

43 - 56

Keywords

Animals, Antigens, Protozoan, Disease Models, Animal, Humans, Immunization, Malaria Vaccines, Malaria, Falciparum, Malaria, Vivax, Plasmodium falciparum, Plasmodium vivax, Sporozoites, Vaccines, Subunit