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Bcl-2, one of a family of key regulators of apoptosis, was the first cell-death machinery component to be identified, but how the family functions is still not clear. Mammalian Bax, a pro-apoptotic family member, can cause yeast cells to die, and two recent yeast genetic screens shed light on how Bax might function.


Journal article


Curr Biol

Publication Date





R528 - R531


Amino Acid Sequence, Animals, Apoptosis, Molecular Sequence Data, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, bcl-2-Associated X Protein