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Bcl-2, one of a family of key regulators of apoptosis, was the first cell-death machinery component to be identified, but how the family functions is still not clear. Mammalian Bax, a pro-apoptotic family member, can cause yeast cells to die, and two recent yeast genetic screens shed light on how Bax might function.

Type

Journal article

Journal

Curr Biol

Publication Date

16/07/1998

Volume

8

Pages

R528 - R531

Keywords

Amino Acid Sequence, Animals, Apoptosis, Molecular Sequence Data, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, bcl-2-Associated X Protein