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Inhaled nitric oxide is rapidly gaining popularity as a selective pulmonary vasodilator in patients with acute lung injury and pulmonary hypertension. The development of nitric oxide as a drug has bypassed the usual regulatory and commercial processes, and as a result clinicians have devised a wide range of delivery and monitoring systems. This review describes these systems, and discusses their advantages, disadvantages and safety. The monitoring of nitric oxide metabolites is also discussed.


Journal article


Intensive Care Med

Publication Date





77 - 86


Administration, Inhalation, Adult, Humans, Infant, Newborn, Monitoring, Physiologic, Nitric Oxide, Respiration, Artificial, Safety