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Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment.

Original publication

DOI

10.1080/15548627.2018.1450021

Type

Journal article

Journal

Autophagy

Publication Date

2018

Volume

14

Pages

1460 - 1461

Keywords

Apoptosis, Crohn's disease, autophagy, colitis, intestinal epithelial cell, ulcerative colitis, Animals, Apoptosis, Autophagy, Colitis, Epithelial Cells, Genome-Wide Association Study, Mice