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The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.

Original publication

DOI

10.1016/j.cell.2009.02.001

Type

Journal article

Journal

Cell

Publication Date

20/02/2009

Volume

136

Pages

688 - 700

Keywords

Animals, Feedback, Gene Expression Regulation, Humans, Protein Biosynthesis, RNA Precursors, RNA Processing, Post-Transcriptional, RNA Stability, Transcription, Genetic