Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

In a blind trial, 77 patients were randomised to receive first cadaver kidney allografts that had been perfused either with a pair of CD45 monoclonal antibodies (mAbs), in an attempt to reduce the immunogenicity of passenger leucocytes, or with control human albumin solution. No complications of mAb perfusion were observed. Patient and allograft survival were similar in both groups. Rejection episodes were recorded in 7 (18%) of the patient with mAb perfused allografts compared with 24 (63%) of the controls.

Type

Journal article

Journal

Lancet

Publication Date

21/10/1989

Volume

2

Pages

935 - 937

Keywords

Animals, Antigens, Differentiation, Creatinine, Dendritic Cells, Evaluation Studies as Topic, Graft Rejection, Histocompatibility Antigens, Humans, Immunosuppression, Incidence, Kidney Transplantation, Leukocyte Common Antigens, Perfusion, Premedication, Randomized Controlled Trials as Topic, Rats, Transplantation, Homologous