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In a blind trial, 77 patients were randomised to receive first cadaver kidney allografts that had been perfused either with a pair of CD45 monoclonal antibodies (mAbs), in an attempt to reduce the immunogenicity of passenger leucocytes, or with control human albumin solution. No complications of mAb perfusion were observed. Patient and allograft survival were similar in both groups. Rejection episodes were recorded in 7 (18%) of the patient with mAb perfused allografts compared with 24 (63%) of the controls.

Type

Journal article

Journal

Lancet

Publication Date

21/10/1989

Volume

2

Pages

935 - 937

Keywords

Animals, Antigens, Differentiation, Creatinine, Dendritic Cells, Evaluation Studies as Topic, Graft Rejection, Histocompatibility Antigens, Humans, Immunosuppression, Incidence, Kidney Transplantation, Leukocyte Common Antigens, Perfusion, Premedication, Randomized Controlled Trials as Topic, Rats, Transplantation, Homologous