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Members of the ZFY and ZNF6 gene families have been cloned from species representing different taxa and different modes of sex determination. Comparisons of these genes show the ZFY-like and ZNF6 sequences to be strongly conserved across marsupials, birds, and lepidosaurians. Sequence analyzed by neighbor-joining indicated that both gene families are monophyletic with a high bootstrap value. Pairing of sequences from males and females of nonmammalian species showed there to be no significant difference between male and female sequences from a single species, consistent with autosomal locations. The molecular distances between murine Zfy-1, Zfy-2, and other ZFY-like sequences suggested that Zfy genes have undergone a period of rapid evolutionary change not seen in human ZFY.

Original publication




Journal article


Mol Biol Evol

Publication Date





129 - 137


Amino Acid Sequence, Animals, DNA-Binding Proteins, Drosophila melanogaster, Evolution, Molecular, Female, Humans, Kruppel-Like Transcription Factors, Male, Mice, Molecular Sequence Data, Multigene Family, Phylogeny, Polymerase Chain Reaction, Sequence Alignment, Sequence Homology, Amino Acid, Species Specificity, Transcription Factors, Vertebrates, X Chromosome, Y Chromosome, Zinc Fingers