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The cytoprotective effect of NBQX, a selective AMPA receptor antagonist, was tested following 10 min of severe forebrain ischemia using the 4-vessel occlusion model. Immediately, and at 15 and 30 min following reperfusion, adult Wistar rats received intraperitoneal injections of either saline (n = 5), 1 mg lithium chloride (n = 17) or 30 mg/kg of the lithium salt of NBQX (n = 18). In saline-treated animals 82 +/- 12% of CA1 hippocampal neurons were lost. Of those treated with lithium 70 +/- 23% were injured, while those given NBQX sustained only 40 +/- 34% CA1 necrosis (P less than 0.01). Twelve of 18 NBQX-treated animals had less than 30% CA1 injury as compared with 1 of 17 lithium-treated animals. The AMPA receptor may play a more important role than the NMDA receptor in selective ischemic necrosis of hippocampal neurons.

Type

Journal article

Journal

Neurosci Lett

Publication Date

11/11/1991

Volume

132

Pages

255 - 258

Keywords

Animals, Cell Death, Chlorides, Hippocampus, Ischemic Attack, Transient, Lithium, Lithium Chloride, Neurons, Quinoxalines, Rats, Rats, Inbred Strains, Receptors, AMPA, Receptors, Neurotransmitter, Reperfusion, Sodium Chloride