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The physiological responses of cells to external and internal stimuli are governed by genes and proteins interacting in complex networks whose dynamical properties are impossible to understand by intuitive reasoning alone. Recent advances by theoretical biologists have demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms. These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally.


Journal article


Curr Opin Cell Biol

Publication Date





221 - 231


Animals Biological Clocks/physiology Eukaryotic Cells/*metabolism Feedback, Physiological/physiology Genomics/*methods/trends Humans *Models, Biological Proteomics/*methods/trends Signal Transduction/*physiology