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The physiological responses of cells to external and internal stimuli are governed by genes and proteins interacting in complex networks whose dynamical properties are impossible to understand by intuitive reasoning alone. Recent advances by theoretical biologists have demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms. These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally.

Type

Journal article

Journal

Curr Opin Cell Biol

Publication Date

2003

Volume

15

Pages

221 - 231

Keywords

Animals Biological Clocks/physiology Eukaryotic Cells/*metabolism Feedback, Physiological/physiology Genomics/*methods/trends Humans *Models, Biological Proteomics/*methods/trends Signal Transduction/*physiology