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Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a stationary polymerase; individual polymerases tie the chromatin fibre into loops and clusters of polymerases determine the basic structure of the interphase and metaphase chromosome. RNA polymerase is then both a player and a manager of the chromosome loop.

Original publication

DOI

10.1002/bies.950160611

Type

Journal article

Journal

Bioessays

Publication Date

06/1994

Volume

16

Pages

425 - 430

Keywords

Artifacts, Bacterial Proteins, Cell Nucleolus, Chromatin, Chromosomes, DNA, DNA Replication, DNA-Directed RNA Polymerases, Enzymes, Immobilized, Microspheres, Models, Genetic, Movement, Photomicrography, Protein Binding, RNA, Specimen Handling, Templates, Genetic, Transcription, Genetic