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Replication of human immunodeficiency virus type 1 (HIV-1) is restricted to CD4-expressing primate cells. This tropism may be due partly to the absence from nonprimate cells of a species-specific factor which has an accessory role to CD4 during virus penetration. In this study we describe a rat B lymphocyte cell line in which there is efficient CD4-dependent entry of HIV-1. However, this cell line has a block to productive infection of HIV-1 at a stage between reverse transcription and integration. Our results demonstrate that the putative accessory factor for HIV-1 penetration is not restricted to primate cells and that there is a novel, uncharacterized cell-virus interaction at a stage between penetration and integration.

Original publication

DOI

10.1099/0022-1317-75-10-2615

Type

Journal article

Journal

J Gen Virol

Publication Date

10/1994

Volume

75 ( Pt 10)

Pages

2615 - 2623

Keywords

Animals, Antibodies, Monoclonal, Antigens, CD, B-Lymphocytes, Base Sequence, CD4 Antigens, Cell Line, Cricetinae, DNA Primers, DNA, Viral, HIV Reverse Transcriptase, HIV-1, HeLa Cells, Humans, Kidney, Molecular Sequence Data, Multiple Myeloma, Polymerase Chain Reaction, RNA-Directed DNA Polymerase, Rats, Virus Integration, Virus Replication, Zidovudine