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Infectious tolerance describes an in vivo process in which tolerance is passed on from one population of lymphocytes to another. In this way, short-term therapy aimed at generating infectious tolerance has the potential to achieve long term, self-perpetuating immune homeostasis in a clinical setting. In recent years, a number of differing strategies have successfully achieved tolerance in vivo. These include harnessing regulatory T cells and tolerogenic antigen presenting cells, promoting tolerogenic interactions or inhibiting activation of effector cells. Many of these are just beginning to face the harsh realities of the therapeutics industry.

Original publication

DOI

10.1016/j.coi.2010.08.002

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

10/2010

Volume

22

Pages

560 - 565

Keywords

Animals, Humans, Immune Tolerance, Infection