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Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes.

Original publication

DOI

10.1016/j.cmet.2017.05.014

Type

Journal article

Journal

Cell Metab

Publication Date

05/07/2017

Volume

26

Pages

17 - 23

Keywords

diabetes, glycogen, insulin, pancreatic β cell